Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis

Crit Care. 2018 Oct 11;22(1):258. doi: 10.1186/s13054-018-2191-x.

Abstract

Two recent publications by Sheikh and Horner and Teng et al. reviewed studies on incorporating vitamin C to treat septic patients; however, a meta-analysis was not offered in either report. This commentary extends both reviews by integrating a meta-analysis and sharing aggregated results. Pooled analyses demonstrated a marked reduction in mortality and duration of vasopressor administration in the group with the use of vitamin C.

Keywords: Ascorbic acid; Meta-analysis; Sepsis; Sepsis management; Severe sepsis; Vitamin C.

Publication types

  • Letter
  • Comment

MeSH terms

  • Ascorbic Acid
  • Humans
  • Sepsis*
  • Shock, Septic*
  • Vasoconstrictor Agents
  • Vitamins

Substances

  • Vasoconstrictor Agents
  • Vitamins
  • Ascorbic Acid