Vitamin C, TITRATING TO BOWEL TOLERANCE, ANASCORBEMIA, and ACUTE INDUCED SCURVY
References (32)
Detoxification of histamine with ascorbic acid
Biochemical Pharmacology
(1973)Clinical trial of vitamin C
Medical Tribune
(June 25, 1975)Clinical use of large doses of ascorbic acid
Vitamin C as a detoxifying agent
Vitamin C — The missing stress hormone
The method of determining proper doses of vitamin C for the treatment of disease by titrating to bowel tolerance
J. Orthomolecular Psychiatry
(1981)Virus pneumonia and its treatment with vitamin C
J. South. Med. and Surg.
(1948)The treatment of poliomyelitis and other viral diseases with vitamin C
J. South. Med. and Surg.
(1949)Observations on the dose and administration of ascorbic acid when employed beyond the range of a vitamin in human pathology
J. App. Nutr.
(1971)Significance of high daily intake of ascorbic acid in preventive medicine
J. Int. Acad. Prev. Med.
(1974)
Studies of a mammalian enzyme system for producing evolutionary evidence on man
Am. J. Phys. Anthro.
Hypoascorbemia: The genetic disease causing the human requirement for exogenous ascorbic acid
Perspectives in Biology and Medicine
Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer
Cited by (65)
Vitamin C and mitochondrial function in health and exercise
2023, Molecular Nutrition and Mitochondria: Metabolic Deficits, Whole-Diet Interventions, and Targeted NutraceuticalsOxidation and “Unconventional” Approaches to Infection
2022, Encyclopedia of Infection and ImmunityPossible application of high-dose vitamin C in the prevention and therapy of coronavirus infection
2020, Journal of Global Antimicrobial ResistanceCitation Excerpt :Pneumonia patients have been observed receiving as much as 100 g/day of vitamin C without developing diarrhoea or reported adverse side effects. A possible mechanism has been attributed to the changes in vitamin C metabolism caused by a severe infection [69]. Other possible side effects that have been reported with extremely high doses of IV vitamin C include dizziness, nausea, dry mouth, perspiration and weakness [70].
A rapid method for the simultaneous determination of l-ascorbic acid and acetylsalicylic acid in aspirin C effervescent tablet by ultra performance liquid chromatography-tandem mass spectrometry
2013, Spectrochimica Acta - Part A: Molecular and Biomolecular SpectroscopyCitation Excerpt :Fatigue, easy bruising, and bleeding gums are early signs of vitamin C deficiency that occur long before frank scurvy develops. Nevertheless, the overdoses of vitamin C may cause diarrhea and other gastrointestinal disturbances [8]. Also the intake of large amounts of AA can deplete copper in the body an essential element [9,10].
Combined inhalational and oral supplementation of ascorbic acid may prevent influenza pandemic emergency: A hypothesis
2010, NutritionCitation Excerpt :Therefore, we are of the opinion that, if a sustained high dose of vitamin C is available in the respiratory secretion, it can exhibit substantial anti influenza virus activity. Oral megadoses of ascorbic acid in a normal population are not advisable because these have been reported to cause diarrhea in normal individuals and there is no conclusive study reporting that oral high doses of ascorbic acid deliver sufficient amounts of ascorbic acid to bronchial secretion [63]. An exploration of the antitumor activity of ascorbic acid through intravenous route has been proposed [64].
Vitamin C as prophylaxis and adjunctive medical treatment for COVID-19?
2020, NutritionCitation Excerpt :High doses of vitamin C are generally assumed to be administered intravenously because they are poorly tolerated orally. However, Cathcart argued that bowel tolerance for vitamin C increased with the severity of illness in many patients, so that oral doses of up to 200 g/d could be tolerated by some patients [73]. This administration route may be preferable for patients treated at home or in facilities where intravenous administration may be difficult.