The shifting sands of 'gain-of-function' research

Nature. 2021 Oct;598(7882):554-557. doi: 10.1038/d41586-021-02903-x.
No abstract available

Keywords: SARS-CoV-2; Virology.

MeSH terms

  • Adaptation, Physiological / genetics
  • Adenosine Monophosphate / analogs & derivatives
  • Adenosine Monophosphate / pharmacology
  • Adenosine Monophosphate / therapeutic use
  • Alanine / analogs & derivatives
  • Alanine / pharmacology
  • Alanine / therapeutic use
  • Animals
  • Biomedical Research / ethics*
  • Biomedical Research / trends*
  • Censorship, Research
  • Coronavirus / genetics*
  • Coronavirus / pathogenicity*
  • Dipeptidyl Peptidase 4 / genetics
  • Dipeptidyl Peptidase 4 / metabolism
  • Evolution, Molecular
  • Ferrets / virology
  • Gain of Function Mutation*
  • Host Specificity / genetics
  • Humans
  • Influenza A Virus, H5N1 Subtype / genetics
  • Influenza A Virus, H5N1 Subtype / pathogenicity
  • Mice
  • Mutagenesis
  • Respiratory Tract Infections / transmission
  • Respiratory Tract Infections / virology
  • Risk Assessment
  • Spike Glycoprotein, Coronavirus / genetics
  • Spike Glycoprotein, Coronavirus / metabolism
  • Viral Vaccines / genetics
  • Viral Vaccines / immunology

Substances

  • Spike Glycoprotein, Coronavirus
  • Viral Vaccines
  • remdesivir
  • Adenosine Monophosphate
  • DPP4 protein, human
  • Dipeptidyl Peptidase 4
  • Alanine