The effect of high doses of vitamin B6 on autistic children: a double-blind crossover study

Am J Psychiatry. 1978 Apr;135(4):472-5. doi: 10.1176/ajp.135.4.472.

Abstract

The authors used data from an earlier nonblind study to identify 16 autistic-type child outpatients who had apparently improved when given vitamin B6 (pyridoxine). In a double-blind study each child's B6 supplement was replaced during two separate experimental trial periods with either a B6 supplement or a matched placebo. Behavior was rated as deteriorating significantly during the B6 withdrawal.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Autistic Disorder / drug therapy*
  • Child
  • Child, Preschool
  • Clinical Trials as Topic
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Evaluation
  • Female
  • Humans
  • Male
  • Placebos
  • Pyridoxine / administration & dosage
  • Pyridoxine / therapeutic use*

Substances

  • Placebos
  • Pyridoxine