Abstract
The authors used data from an earlier nonblind study to identify 16 autistic-type child outpatients who had apparently improved when given vitamin B6 (pyridoxine). In a double-blind study each child's B6 supplement was replaced during two separate experimental trial periods with either a B6 supplement or a matched placebo. Behavior was rated as deteriorating significantly during the B6 withdrawal.
Publication types
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Clinical Trial
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Controlled Clinical Trial
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Autistic Disorder / drug therapy*
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Child
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Child, Preschool
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Clinical Trials as Topic
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Dose-Response Relationship, Drug
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Double-Blind Method
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Drug Evaluation
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Female
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Humans
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Male
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Placebos
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Pyridoxine / administration & dosage
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Pyridoxine / therapeutic use*