Novel tubular-glomerular interplay in diabetic kidney disease mediated by sirtuin 1, nicotinamide mononucleotide, and nicotinamide adenine dinucleotide Oshima Award Address 2017

Clin Exp Nephrol. 2019 Aug;23(8):987-994. doi: 10.1007/s10157-019-01719-4. Epub 2019 Mar 11.

Abstract

Tubules interact with glomeruli, which are composed of podocytes, parietal epithelial cells, mesangial cells, and glomerular endothelial cells. Glomerular-tubular balance and tubuloglomerular feedback are the two components of the tubular-glomerular interplay, which has been demonstrated to play roles in physiological renal function and in diabetic kidney disease (DKD), in which proteins leaking from glomeruli arrive at tubular regions, leading to further tubular injury caused by the accumulation of proteinuria-inducing reactive oxygens species and various cytokines. In the current review, we present our recent work identifying a novel tubular-glomerular interplay in DKD mediated by sirtuin 1 and nicotinamide mononucleotide.

Keywords: Diabetic kidney disease; Nicotinamide mononucleotide; Sirtuin 1; Tubuloglomerular feedback.

Publication types

  • Review

MeSH terms

  • Animals
  • Awards and Prizes
  • Claudin-1 / genetics
  • Claudin-1 / metabolism
  • Diabetic Nephropathies / enzymology*
  • Diabetic Nephropathies / genetics
  • Diabetic Nephropathies / pathology
  • Epigenesis, Genetic
  • Gene Expression Regulation
  • Glucose Transporter Type 2 / genetics
  • Glucose Transporter Type 2 / metabolism
  • Humans
  • Kidney Glomerulus / enzymology*
  • Kidney Glomerulus / pathology
  • Kidney Tubules / enzymology*
  • Kidney Tubules / pathology
  • NAD / metabolism*
  • Nicotinamide Mononucleotide / metabolism*
  • Signal Transduction
  • Sirtuin 1 / genetics
  • Sirtuin 1 / metabolism*
  • Sodium-Glucose Transporter 2 / genetics
  • Sodium-Glucose Transporter 2 / metabolism

Substances

  • CLDN1 protein, human
  • Claudin-1
  • Glucose Transporter Type 2
  • SLC2A2 protein, human
  • SLC5A2 protein, human
  • Sodium-Glucose Transporter 2
  • NAD
  • Nicotinamide Mononucleotide
  • SIRT1 protein, human
  • Sirtuin 1